Q. Which of the following statements is most accurate regarding infection with parvovirus B19?

A) Parvovirus B19 can cause hydrops fetalis via transplacental infection of a fetus in a seropositive mother

B) Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors

C) Parvovirus B19 replicates in the host cell nucleus utilizing a virally encoded DNA polymerase to create a double- stranded DNA intermediate

D) Parvovirus B19 can be diagnosed by detection of viral RNA using PCR or hybridization assays

✔ Correct Answer: Parvovirus B19 causes severe anemia because it preferentially infects erythrocyte precursors

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